Protein Modification Reagents
Medchemexpress LLC Tamra alkyne, 5-isomer | 945928-17-6 | 96.6% | 467.52 g/mol | C28H25N3O4 | 5 MG
TAMRA alkyne, 5-isomer is an alkyne-derivatized tetramethylrhodamine (TAMRA) fluorescent dye designed for click chemistry labeling. It permits efficient conjugation to azide- or DBCO/BCN-containing molecules and is commonly used for in-gel fluorescence detection, enrichment, and identification of labeled proteins.
Medchemexpress LLC Biotin-PEG-azide | 956494-20-5 | 98.7% | 2000.00 | 100 MG
Biotin-PEG-azide (MW 2000) is a biotinylated polyethylene glycol derivative with a terminal azide functional group. Supplied as a powder with an average molecular weight of 2000, it is designed for use in bioconjugation workflows such as copper-catalyzed azide-alkyne cycloaddition and for affinity labeling or capture of biomolecules. Manufacturer datasheets provide purity, storage, and handling details.
Medchemexpress LLC Biotin-PEG-azide | 956494-20-5 | MFCD21363314 | 98.7% | 2000.00 | Not specified - polydisperse PEG derivative (no fixed chemical formula) | 50 MG
Biotin-PEG-azide (MW 2000) is a biotin-labeled polyethylene glycol derivative with a terminal azide functional group for bioorthogonal conjugation. The reagent is supplied as a powder and is intended for use in click-chemistry bioconjugation workflows, enabling efficient biotinylation of alkyne-containing molecules and surfaces for downstream affinity capture and detection.
- Contains terminal azide for copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted alkyne-azide cycloaddition (SPAAC).
- Peg spacer provides hydrophilicity and reduces nonspecific interactions.
- Average molecular weight 2000 Da (polydisperse polymer).
- High purity, suitable for research applications.
- Stable as a powder at -20°C for long-term storage.
- Useful for protein labeling, affinity capture, and general bioconjugation.
Medchemexpress LLC DSPE-PEG-FITC | 95.0% | 600 (average) | 50 MG
DSPE-PEG-FITC (MW 600) is a fluorescein-labeled PEGylated lipid used as a fluorescent probe for incorporation into liposomes, lipid nanoparticles, and membrane-labeling applications. It is supplied as a light yellow to yellow solid, has an average molecular weight of ~600, and is intended for laboratory research use.
- Provides fluorescent labeling via FITC for visualization and tracking.
- PEGylated lipid anchor enables stable incorporation into membranes and nanoparticles.
- Average molecular weight approximately 600 for predictable behavior in formulations.
- Light yellow to yellow solid suitable for standard laboratory handling.
- Recommended storage at 4°C with protection from light; in solvent: -80°C up to 6 months or -20°C up to 1 month.
- Purity tested at 95.0% per manufacturer certificate of analysis.
Medchemexpress LLC Tri(GalNAc-PEG2)-PEG4-cyclo(Ac-DCAW-Arg(3F-Ph)-PEG2-LGELVWCT) (Cys2-Cys12) | 99.5% | 3488.76 | C152H236FN25O62S2 | 5 MG
This synthetic peptide-GalNAc conjugate is an asialoglycoprotein receptor (ASGPR) ligand intended for lysosome targeting chimera (LYTAC) research. It combines tri-N-acetylgalactosamine units with PEG spacers and a cyclic peptide core to enable ASGPR-mediated uptake of conjugated cargos.
- Is an ASGPR ligand suitable for lysosome targeting chimera research.
- Peptide-based conjugate bearing tri-N-acetylgalactosamine (tri-GalNAc) moieties linked through PEG spacers.
- Molecular weight 3,488.76.
- Purity 99.46% by HPLC.
- Appearance white to off-white solid; hygroscopic in solution.
- Soluble in DMSO at 33.33 mg/mL (9.55 mM); ultrasonic agitation recommended.
- Store at -20°C protected from light; in solvent: -80°C (6 months) or -20°C (1 month).
- For research use only; not for human or clinical use.
Medchemexpress LLC Dnp-peg4-acid | 858126-76-8 | 1 G
DNP-PEG4-acid is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. PROTACs are compounds featuring two ligands connected by a linker: one targeting an E3 ubiquitin ligase and the other targeting a specific protein. These compounds utilize the intracellular ubiquitin-proteasome system to facilitate the selective degradation of target proteins.
- Peg-based PROTAC linker
- Used for the synthesis of PROTACs
- Leverages the intracellular ubiquitin-proteasome system
- Facilitates selective degradation of target proteins
- Appearance: viscous liquid
- Color: colorless to light yellow
Medchemexpress LLC Pomalidomide-amido-PEG3-C2-NH2 | 2328070-52-4 | 99.6% | 476.48 g·mol-1 | C22H28N4O8 | 5 MG
Pomalidomide-amido-PEG3-C2-NH2 is a pomalidomide-derived cereblon ligand-linker conjugate intended for PROTAC and chemical biology research. It couples a cereblon-binding motif to a three-unit PEG linker with a two-carbon spacer, offering a convenient chemical handle for attachment to target-binding ligands. The compound is supplied as an off-white to light yellow solid with high purity suitable for laboratory studies.
- High purity (99.6% by HPLC).
- Molecular weight 476.48 g·mol-1.
- Molecular formula C22H28N4O8.
- Physical form solid, off-white to light yellow.
- Provides a PEG3 linker and C2 spacer for conjugation.
- Designed for use as a cereblon ligand in PROTAC design.
- Available in small research quantities such as 5 mg.
Medchemexpress LLC N3-PEG11-CH2CH2Br | 2098982-00-2 | MFCD32696701 | >98.0% | 634.56 g/mol | C24H48BrN3O11 | 100 MG
N3-PEG11-CH2CH2Br is an azide-terminated polyethylene glycol (PEG11) linker bearing a terminal bromoethyl group. Supplied as a high-purity research reagent (purity >98%), it is intended for bioconjugation, probe synthesis, and other linker chemistry where azide reactivity and alkyl bromide substitution are required. The hydrophilic PEG spacer enhances solubility in aqueous media, facilitating handling in biochemical assays. Typical pack size: 100 mg.
- Azide-terminated linker for click chemistry.
- Terminal bromoethyl group enables nucleophilic substitution.
- PEG11 spacer improves aqueous solubility.
- High purity suitable for research applications.
- Supplied in small-scale vials for synthesis and probe development.
Medchemexpress LLC (2R)-3-(((2-(2-azidoacetamido)ethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl distearate | 2839508-98-2 | 96.4% | 831.11 | C43H83N4O9P | 10 MG
DSPE-N3 is an azide-functionalized phospholipid (C43H83N4O9P; CAS 2839508-98-2) intended for research use. It provides an azide handle for covalent conjugation via copper-catalyzed or strain-promoted azide-alkyne cycloaddition, enabling facile functionalization of liposomes, nanoparticles, and surfaces.
Medchemexpress LLC DSPE-biotin | 133695-76-8 | MFCD34561787 | 97.5% | 974.36 | C51H96N3O10PS | 10 MG
DSPE-Biotin is a biotinylated phospholipid used to introduce biotin functionality into liposomes, lipid bilayers, and other lipid-based formulations for biochemical research and bioconjugation. It facilitates specific capture, labeling, and immobilization through high-affinity streptavidin/avidin interactions.
- Provides biotin functionality for liposomes and lipid bilayers.
- Enables high-affinity binding to streptavidin and avidin.
- Suitable for liposome formulation and surface immobilization applications.
- Soluble in DMSO; ultrasonic warming improves solubility.
- High purity for research use; handle and store protected from light.
- Stable when stored at -20°C for long-term storage.
Medchemexpress LLC Dspe-peg-sh | 99.4% | 2000 (average) | (C2H4O)nC45H87N2O10PS | 25 MG
DSPE-PEG-SH is a thiolated pegylated phospholipid (average MW 2000) that provides a terminal -SH for covalent surface modification of lipid assemblies. Its amphipathic DSPE-PEG structure enables incorporation into liposomes and lipid nanoparticles for ligand attachment, stabilization, and targeted delivery via formation of stable thioether bonds with maleimide-functionalized molecules.
- Provides a terminal thiol for covalent conjugation.
- Incorporates into lipid bilayers for surface functionalization.
- Enables stable thioether linkage with maleimide reagents.
- Suitable for liposome and lipid nanoparticle formulations.
- Facilitates targeted delivery via ligand attachment.
- Reported high purity supports reproducible formulation.
- Soluble in water and DMSO with warming and sonication.
eMolecules N-Boc-PEG36-alcohol | | MFCD29052163 | 1g
Broadpharm | N-Boc-PEG36-alcohol | 1g | 296213186 | BP-22981 | 96.000 | | MFCD29052163 | 1703.056 | C77H155NO38
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eMolecules Azido-PEG1-Val-Cit-PAB-OH | 2055041-40-0 | MFCD29918231 | 500mg
Broadpharm | Azido-PEG1-Val-Cit-PAB-OH | 500mg | 550804304 | BP-23205 | 98.000 | 2055041-40-0 | MFCD29918231 | 520.591 | C23H36N8O6
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Medchemexpress LLC m-PEG-DMG | 1019000-64-6 | 98.0% | 2000 Da (average) | (C2H4O)nC36H73NO5 | 100 MG
m-PEG-DMG (MW 2000) is a methoxy-terminated polyethylene glycol conjugated to dimyristoylglycerol. Supplied as a solid with an average molecular weight of about 2000 Da, it is formulated for preparation of PEGylated liposomes and lipid nanoparticles used in drug delivery research and related in vitro studies.
- High purity (98.0%).
- Average molecular weight ~2000 Da.
- White to off-white solid form.
- Suitable for liposome and lipid nanoparticle formulation.
- Provides steric stabilization and reduced protein opsonization.
- Available in small laboratory pack sizes (e.g., 5-100 mg).
- Documentation available: data sheet, COA, and SDS.